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While slight improvements are possible by tailoring the kmer size to the region or specific gene of interest, in general, 8-mers provided the best and fastest alignments for 16S rRNA gene fragment sequences.
Assuming that false positives hits generate a low random background, it may be possible to use SANS in its fastest, alignment-free mode to generate hit lists for assigning functions to new genomes.
For both algorithms, we found that the 99% fastest alignments need nearly as much computing time as the remaining 1% slowest alignments.
We conjecture that for larger datasets, the running time spent on computing the 99% fastest alignments will be significantly smaller than the running time spent on the 1% slowest alignments.
The exhibition labels avoid hard-and-fast alignment of peoples, places and styles.
The created vacuum enables fast alignment of high-AR AuNRs on a large scale.
A focused laser beam is employed as a reference for automatic and fast alignment of the AFM cantilever tip with the micro-tool cutting edge.
The use of the Pyrex-SU-8 clamping substrate allows an easy replacement of the cantilever chips and a fast alignment process to the DVD-ROM laser beam.
Hence, larger responses lead to a faster alignment between the clock phase and the LD cycle.
Thus, the size of the ODN is a critical parameter to guarantee a fast alignment between the two molecules.
The estimated scale of the problem aligning a billion reads per day on a moderate computer cluster obviously demands extremely fast alignment algorithms, but more importantly demands high accuracy of the alignments (i.e. obtaining the true alignment of a read, among the many various candidates).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com