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In-vitro drug release from materials containing varying concentrations of MX revealed that the scaffolds containing higher amount of drug showed comparatively faster release.
Press the throttle, and it goes faster; release the throttle, and it goes slower.
As it can be found in Figure 4, there was a relatively faster release at the first 1 hour.
HS-induced EPSCs display concentration-dependent changes in release kinetics, with higher degrees of hypertonicity leading to faster release, causing a decrease in time-to-peak and an increase in peak release rate (Basu et al., 2007).
In contrast, the pH 4.7 surfactant-liposome preparation had a much faster release profile in the IVR assay (Fig. 2b) that remained unchanged after 1-year refrigerated storage (Fig. 2c, d).
In case of more random PLACL 75 : 25, higher molar mass dispersity (D = 2.5) (Table 1) indicates higher amount of shorter copolymer chains, in which faster release might have caused uneven drug release.
The faster release rate for carbofuran was attributed to its higher water diffusivity.
Whatever the formulation, greater and faster release of indomethacin was noticed in sodium taurocholate-rich medium and in fed rats.
In vitro drug delivery studies showed a faster release rate at pH 5.0 than that at pH 7.4.
A much faster release rate was measured when exposure time in acid was 10 min compared with 60 min.
This can be attributed to the silicone oil preventing the hydration on the silicone tubing, which can lead to faster release of NO from the donor16,18.
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