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We also extended these studies to differentiated primary mouse muscle cell cultures; we observed two types of myotubes in primary cultures: thin slowly contracting myotubes with nuclei aligned along the middle of the fiber (immature myotubes), and thicker, faster contracting myotubes often with small or large nuclei clusters (mature myotubes).
Trappe et al. (2004) found directional shift from slower contracting fiber to a faster contracting fiber.
Faster contracting, relatively longer muscle fascicles, and muscles with a greater capacity for force generation might be expected to have elevated power demands.
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Instead, it has the world's fastest contracting economy, the second highest murder rate, inflation heading towards 1,000% and shortages of food and medicine that have pushed the poorest members of its 30 million population to the edge of a humanitarian abyss.
EDL is normally a fast contracting muscle in adult rats, whereas soleus is a slow one.
However, surprisingly the excitability of motor neurons innervating fast contracting muscle fibers does not change.
An example is given below, where the pdf is concentrated on a non-linear manifold due to fast, contracting directions.
Slow motor neurons innervating slow contracting muscle fibers are much more resistant to degeneration than motor neurons innervating fast contracting muscle fibers during development of ALS.
It should be stressed that the 10F5 antibody did not label any fiber in large limb muscles (biceps femoris, vastus intermedius, vastus lateralis), but it did in human EOM, indicating that MyHC-2b isoform is expressed in these "specific, very fast contracting" muscles.
These recommendations included continuing the 60-Day Challenge to allow for parallel submission and review of the budget, contract, and regulatory documents; incorporating previously approved contract language and master agreements whenever possible to help facilitate faster contract negotiations; and creating a focused pool of dedicated CTA processing staff.
Concerning the time evolution of contraction, we reconfirmed that immature (P14) muscles are not yet differentiated into fast- or slow-contracting ones and that fast contracting muscles are more severely affected by axotomy [ 1, 3, 31].
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