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Moreover, the cryogels exhibit fast swelling rate, and their equilibrium swelling ratio is related to DCMC content and pH-dependent.
cRGD-MMP exhibited excellent stability in 10% fetal bovine serum and cell culture medium while fast swelling and markedly accelerated drug release under a reductive environment.
Fast swelling was observed for F15 that reached 1160.53 ± 13.02% in 4 h with 2 h bioadhesion time to mouse peritoneum membrane compared with 458.83 ± 7.09% swelling with bioadhesion time exceeding 24 h for F5.
Arguably, the subsequent relatively fast swelling was induced by CO2 dissolution in the coal matrix (Reucroft and Patel 1986; Walker et al. 1988a, b; Romanov and Soong 2008).
Several important properties of SPHs, such as fast swelling, large swelling ratio, and surface slipperiness, make them excellent candidate materials to develop drug delivery devices [ 9].
The fast swelling of the unmodified tablet might be the reason for a fast release of the drug within the first 2 h followed by a slower but still increasing release over the last 4 h.
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A faster swelling rate was observed for all IPN formulations compared with the single-network gels.
Under water-saturated conditions, the EDC derivatives showed faster swelling kinetics and reached almost the same water holding capacity as the original sample after 18 days.
These characteristics could promote faster swelling, leading to the creation of an amorphous structure during the 20-hour interval).
It is also clearly seen in Figure 5 that IPN hydrogel exhibits a faster swelling rate than semi-IPN and KPAsp hydrogel.
In this sense, even including the values reported by Sun et al. our results closely parallel those obtained by Frijns et al. (1997) [ 33], who reported an earlier and faster swelling.
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