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This is in accord with earlier observed removal of at least one H2A/H2B dimer by the chromatin transcription-enabling activity (CTEA) complex [CTEA], [ 15], [18,29] to allow Pol II passage and the fast reconstitution of nucleosomes by CTEA and the FACT histone chaperone shortly after Pol II passage [29], [50].
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One study found unrelated CBT leads to faster B-cell reconstitution and slower CD8 T-cell reconstitution compared with unrelated BMT [185], while another that PBSCT led to faster reconstitution than BMT [186].
The faster reconstitution capacity of CD28- cells than of naïve and memory cells after DNA-damaging chemotherapy has been previously demonstrated [ 58].
Hematopoietic reconstitution was fast and no graft failure occurred.
> -wrap-foot> Thistudydy shows the efficacy of a single intracerebral injection of LV.GALC in a highly interconnected white matter region of GALC-deficient neonates in achieving fast, widespread and stable reconstitution of enzymatic activity.
One such study found that B cell reconstitution is faster after CBT than BMT [176].
Another found that reconstitution was faster with matched sibling donors rather than family mismatched or unrelated donors [177], whilst others found T-cell reconstitution at 6 months was significantly delayed in patients having autologous PBSCT compared with allogeneic BMT or PBSCT [178].
Compound 1 displayed similar, faster kinetics in the microtubule reconstitution experiment, indicating that it binds and stabilizes the microtubule network, as paclitaxel does.
AFS acid-fast stain, MTB Mycobacterium tuberculosis, IRIS Immune reconstitution inflammatory syndrome, HBV hepatitis B virus infection, HCV hepatitis C virus infection.
The reconstitution of AQP0 into large unilamellar liposomes promotes a fast liposome aggregation at acid pH (86), which is the pH at which the permeability of the channel is the highest.
A study comparing reconstitution at 90 days found that unrelated CBTs had faster B-cell and Natural Killer (NK) cell reconstitution, but delayed T-cell reconstitution when compared to matched sibling BMTs and unrelated BMTs.
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