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SNPs below 100 μg/mL showed high cytocompatibility and fast internalization via clathrin-mediated pathway.
In certain situations (e.g., K off ≪ K int), increasing affinity by decreasing K off may yield no benefit because of the fast internalization of the target (Grimm, 2009).
From our point of view and with regard to relatively fast internalization and differentiation of Leishmania parasites, studying exosome/exoproteome release in longer time points should be done on amastigotes rather than promastigotes.
We hypothesized that a fast internalization of the available TCR molecules upon stimulation with sAbs could provide an explanation for the rapid termination of TCR-mediated signaling.
These results can be related to the fast internalization of PTX-NS, that ensure a quicker and higher drug concentration available inside the cells.
To investigate whether UVB interferes with the kinetics of IL-1R internalization, and to validate the model prediction of fast internalization, FACS analysis was performed.
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Particles with larger ARs were taken up in larger amounts and had faster internalization rates.
It is interesting to note that [111In]AT2S showed faster internalization of total-added radioactivity as compared with [111In]AT1S.
Micelles with smaller size tended to accumulate easily in tumor sites due to the enhanced permeability and retention (EPR) effect and gained a faster internalization rate into cells [30, 31].
Comparative analyses of endocytosis efficiencies revealed that the described phenomenon is most likely due to a faster internalization process of full length TcdA compared to truncated TcdA1 1874.
IGF-II promotes a faster internalization of IR-B than insulin.
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CEO of Professional Science Editing for Scientists @ prosciediting.com