The first formulation is based on a nucleotide-level alignment model; a second, potentially faster formulation is based on chaining fragments shared between each transcript and the reference genome.
Simulations which accurately depict observed data under a variety of dosing scenarios including different dietary states (fed, fasted), formulations, and doses (nonlinearities) increase confidence in the model structure and parameterization.
A new O(N) fast multipole formulation is proposed for non-oscillatory kernels.
A new fast multipole formulation for solving elliptic difference equations on unbounded domains and its parallel implementation are presented.
The validity of the asymptotic formula is confirmed by comparison with the numerical results computed by the fast field formulation and the direct evaluation of the integral.
Gelucire containing only PEG esters are generally used in the preparation of fast release formulations.
With both analyses, values of the slope were nearly equal to 1, confirming that in vivo release for the slow and fast release formulations (50 50 and 75:25 PLGA) followed a similar trend, with minimal lag.
A recent publication analyzing the pharmacokinetics of serum LA concentration in the same subjects presented in this study demonstrates that serum LA concentrations peaked at an earlier time point (about 30 minutes faster) for formulation C compared to formulations A or B [34].
Using this approach, an ultra-fast insulin formulation for s.c. injection was developed (VIAject; Biodel, Danbury, CT, USA) [ 2].
In a double-blind, randomized crossover study, two formulations of faster-acting insulin aspart (only data for the faster aspart formulation undergoing further development were presented) were compared with insulin aspart in CSII in 43 adults for 14 days [ 165].
