Suggestions(1)
Exact(10)
Given the potential for LBA, fast evolving species should be avoided.
However, we have to take into account the possibility that our sequence alignment contains e.g. fast evolving species or strong variation over sites.
As synonymous substitutions accumulate more rapidly than nonsynonymous substitutions, this will lead to a differential saturation of d S and d N, thus potentially resulting in biased estimates of their ratio, particularly along branches corresponding to long periods of time, ancient evolutionary lineages or fast evolving species.
The last worth considering aspect concerning this proposal is related to the fact that in these fast evolving species it is more difficult to identify homologous.
This pedigree reflects the known phylogenetic tree rather well, with the exception of fast evolving species that branch off too early.
Indeed, in fast evolving species, the intron splicing site, whose sequence conservation is essential, has less chance to remain intact, thus impeding the insertion of novel introns [ 35, 36].
Similar(50)
The comparison of branch lengths obtained on the protein- and rRNA-coding mitochondrial partitions, first demonstrates that tunicates are clearly the fastest evolving species of the metazoan dataset on both partitions.
Alternatively, Zhong et al. [ 39] recovered the new chordate phylogeny under the maximum likelihood framework when removing the fastest evolving vertebrates species and when considering only the four most conserved mitochondrial proteins.
However, the value of orthology increases as we consider more divergent species, especially fast evolving ones such as rodents.
The lowest part of the table presents the sequence divergence of two published fast evolving markers used for characterizing species or genera.
However, culture-independent studies in the last three decades showed that, although sequencing strategies are fast evolving, the great majority of bacterial species is still unknown [42, 43].
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