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Copolymerization of ε-caprolactone (ε-CL) with other monomers or fast degrading polymers, i.e., malic acid and PGA, could facilitate polymer degradation and control drug release.
Overall, it was observed that the addition of biosurfactant increased the biodegradation efficiency for slow-degrading consortia, while a notable decrease of biodegradation rate occurred for fast degrading consortia.
To investigate the effects of individual extracellular factors on epithelial morphogenesis, we engineered fast degrading protease-responsive polyethylene glycol (PEG) hydrogels functionalized with controlled densities of various bioligands (RGD peptide, laminin-1 (LN)) to allow 3D culturing of MDCK cells, cyst expansion, and morphogenesis/polarization.
When fast degrading HeMA HA hydrogels containing 75 mg ml−1 microspheres were injected into infarcted tissue in sheep, LV dilation was limited and the thickness of the myocardial wall and the presence of vessels in the apical infarct region were increased ∼35 and ∼60%, respectively, compared to empty hydrogels.
The scaffolds were synthesized from blends of fast degrading polyglycerol sebacate (PGS) and slowly degrading polycaprolactone (PCL).
A thin layer of fast degrading 50/50PLGA was placed as the diffusion layer between the 85/15PLGA layers to prevent any burst-type release.
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The CSO-ss-SA showed an improved reduction-sensitivity which only fast degraded and released drug in 10 mM levels of glutathione (GSH).
Our study demonstrated that the faster degrading PGS component of PGS PCL accelerated the degradation rate of the scaffolds.
The faster degrading hydrogels promoted SMC proliferation and spreading.
These faster degrading gels should provide matrices that are easier for cells to remodel and lead to increased cellular infiltration and potentially more robust healing in vivo.
Marrow stromal cells and endothelial progenitor cells had the highest expression of vasculogenic markers when co-encapsulated in the faster degrading SPELA gel.
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CEO of Professional Science Editing for Scientists @ prosciediting.com