In a stepwise forward fashion, parameters with P values < 0.05 at univariate level were entered into Cox regression model to analyze their relative prognostic importance.
To reduce computational complexity we model the allosteric regulation of the active sites in a simplified fashion (parameters: K iS, K iP, n i, n a, α, β); all other reaction steps and the non-catalytic regulatory mechanisms are as above.
Only for E(T) = 10 is the sampling evenly spread out in a normal fashion across parameter space.
Here, we tested the hypothesis that 5-HT and pCA interact with SERT in an identical fashion (all parameters of the transport model kept unchanged) and that the observed differences between substrates (5-HT and pCA) and between HEK293 cells and Xenopus laevis oocytes can be attributed to internal reservoirs of accumulated amphetamine.
The robust nature of biological systems can ensure that healthy individuals respond in a qualitatively similar fashion despite large parameter variations in the underlying components (Kitano 2004).
In this case, the full model is formulated in such a fashion that the parameters of the model depend on temperature, preconditioning and the temperature-preconditioning interaction effect, whereas the parameters of the reduced model depend on temperature and preconditioning as the only fixed effects terms.
Mr. Lagerfeld, who is best known for his 27-year reign as creative director of Chanel, has an instinct for capturing fashion's shifting parameters.
The Expectation Maximisation (EM) algorithm is used to estimate, in an iterative fashion, the different parameters of this mixture, that is, the means, the variances, and the a priori probabilities.
However, one has to keep in mind that the algorithms themselves must be designed in such a fashion that novel parameters can be efficiently incorporated.
In particular, each scenario was created by ranging parameters from 0 to 0.2, in a step-wise fashion, such that each parameter took on one of 22 possible values within this range, giving rise to 22 3 = 10,648 scenarios.
