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RNA-based studies demonstrated that pfg377 and α-tubII transcripts did not accumulate in a coordinated fashion during development.
Large-scale analyses of DNA methylation patterns have uncovered revealed that DNA methylation patterns are dynamic rather than static and change in a gene-specific fashion during development and in diseased cells.
Genes of higher plants are expressed in a coordinated fashion during development of tissue and organ systems and in response to different environmental conditions.
This shows that while let-7 increases in a temporally defined fashion during development, it can transiently fluctuate after environmental perturbations.
Comparative embryology and developmental genetics, on the other hand, have revealed that transcription factor and signaling networks are expressed and deployed in a highly stereotypic and exquisitely precise spatiotemporal fashion during development.
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Vagaska, B. et al. MHC-class-II are expressed in a subpopulation of human neural stem cells in vitro in an IFNgamma-independent fashion and during development.
Particularly in the brain, numerous different microRNAs are expressed in a cell type specific fashion both during development and in adulthood.
Whilst progress in understanding the molecular basis of ovary development has been slower, several genes have now been demonstrated to function in the pathway of testis development, many of these comprising transcription factors or secreted signalling molecules expressed in a male-specific fashion during gonad development (reviewed in [5], [6]).
Furthermore, this system evolves, and the real hurdle is, therefore, to control it in a dynamic fashion during its development, that is, during the morphogenesis of the tissue.
Our previous studies show that the expression of TbetaR-II is highly regulated in a spatial and temporal fashion during lung development.
Multiple Notch family members act in a redundant fashion during thymic development of CD4 or CD8 T cell.
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