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This targeting of ubiquitination enzymes indicates that the knockdown of FAS affects the tumor cell proteome not only through changes in transcription, but also on the post-translational level.
The major findings of this work are as follows: first, siRNA mediated knockdown of FAS affects the transcription of genes involved in tumor cell energy metabolism as demonstrated by down-regulation in lipid metabolism, glycolysis, krebs-TCA cycle and oxidative phosphorylation pathways.
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Through these actions, FAs affect health, well-being, and the risk of developing disease [10].
Other proposed criteria such as the potential to reveal novel disease mechanisms are also satisfied since FAs affect a variety of metabolic and regulatory pathways linked to CHD (inflammation, plaque instability, arrhythmic susceptibility, dyslipidemia, hypertension, etc).
The study question of this paper focuses on changes over 12 months for patients and how the receipt of FA affects health outcomes measured in terms of change in WHO staging and weight of patients receiving TASO care and treatment services.
Excess amount of n−3 FA affected female offspring more than males.
This study evaluated if increasing the amount of unsaturated FA in the diet as triglycerides or free FA affected feed intake, yield of milk and milk components, and feed efficiency.
FA and SCA3 share pathology in that the purkinje cells are preserved, unlike SCA1 and SCA2, and both SCA3 and FA affect the dentate nuclei and the dorsal nuclei of Clarke (24).
The present study investigated how changes in the dietary FA affect the mRNA level expression of genes related to fat metabolism in the subcutaneous adipose tissue in Boer goats.
In cancer cells major changes in lipid composition, i.e. the presence and/or abundance of saturated vs unsaturated FAs critically affects membrane physiology and plasticity.
The fas mutation affects a YABBY2 transcription factor which encodes a member of the family regulating organ polarity [ 27, 51].
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