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Another pool of β-catenin, thus far thought to be separate and functionally distinct from AJ associated β-catenin [7], is an essential component of the Wnt signaling pathway, a key modulator of development that has also been implicated in cancer [6], [14].
Interestingly, one of these families is present in Sulfolobus genomes, which were so far thought to lack FtsZ/tubulin homologs.
The induction frequency is much higher than that induced by transient transfection using the Amaxa Nucleofector, so far thought to achieve maximum transfection efficiency in DT40 cells [24].
Esthesioneuroblastoma (ENB) is a rare, site-specific, locally aggressive neuronal malignancy so far thought to belong to primitive peripheral neuroectodermal tumour-Ewing's tumour (pPNETs-ETs).
This phenomenon was so far thought to be the result of an evolutionary pressure; we propose that an asymmetric chromosome mis-segregation in cancer stem cells might provide a direct mechanistic explanation for this behaviour.
Immortalization, the first step in tumorigenesis, so far thought to occur because of mutations (Carnero and Lleonart 2010), has been demonstrated to occur upon overexpression of phosphoglycerate mutase or phosphoglucoisomerase (Kondoh et al. 2005).
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But the 1918 pandemic, the worst by far, is thought to have occurred without a gene swap, when a bird flu somehow mutated enough to jump into humans.
The two Britons named so far are thought to be relatively low-level suspects who would most likely be charged with receiving training from Al Qaeda.
The culprit is a bacterium known as Ehrlichia ewingii, which so far was thought to infect only dogs.
I suspect that the authors of this report have given far more thought to this food source than I have.
One of the key issues contributing to the lack of efficacy in the trials conducted so far is thought to be the relatively low doses of vector used in many of the initial trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com