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Otherwise, if it is found to be inadequate, the findings of a single arm PK study can be extrapolated to inform selection of an alternative dosing rule only under strong assumptions, i.e. assumptions that have far reaching clinical consequences yet are supported by limited evidence, in this case dose proportionality.
Senator Sarah Ferguson, chairman of the panel, said: "These are fundamental and far reaching changes to the law and it is essential that we understand the assumptions underlying them and the reasons for the amendment".
His practice was far reaching.
The impact was far reaching.
Our determined responses are far reaching.
The implications could be far reaching.
The ramifications were potentially far reaching.
The report is clearly progressive and far reaching.
The musical scope of that brain is far reaching.
It's far reaching, actually.
The majority of these methods have far reaching negative impacts.
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