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Comparisons with the orthologous regions from the genomes of C. briggsae and C. remanei show that the inverted repeat structures are often far more conserved than the sequences.
However, the sporadic strain was found to be far more conserved compared with the others.
On average, these genes are 85% identical, which indicates that the Route66 LTR-retrotransposon is far more conserved between rice and Sorghum than these seven genes.
Although sequence identities between the CYP51 orthologues in eukaryotic species are low (about 25%), amino acids constituting the substrate binding sites are far more conserved.
For example, amino acids buried in protein cores have been found to be far more conserved than those at surface positions [ 9].
However as PINALOG generated far more conserved interactions (NC) than IsoRank, it is helpful to consider the ratio of NI to NC.
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The SLC6A4 core promoter is far more phylogenetically conserved (Figure 4 B, blue dotted box).
In contrast, non-coding DNA in the D. melanogaster genome is far more uniformly conserved.
While HS sites are far more evolutionarily conserved than non HS sites in the human genome, consistent with their functional importance, TE-derived HS sites are highly divergent.
Cis-acting RNA elements such as the IRES, frameshift sites, TAR and Ψ are far more highly conserved than conventional protein targets, and mutational escape is therefore more difficult.
Differences in diversity were measured within each protein, and the absolute changes were far more dramatic for the antigenic proteins, which had higher baseline diversity, than for the internal proteins, which tended to be more conserved.
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