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Those with long memories will recall the unlikely box-office success of curios such as pot-growing farce Saving Grace and Mike Hodges's elegant Croupier, films that drew large US crowds with a far lower initial profile than Red Riding.
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With second quarter results only a week away, expectations have been lowered again and some forecasts now predict a 2008 year of as low as $1.7B, or even lower – which would present a year-on-year growth rate of just over 30%, far lower than initial expectations.
This is similar to the 0.021 ± 0.008 DSBs per cell division obtained from the microfluidic data above, and both are far lower than initial estimates (Cox et al., 2000), discussed below.
Casualties, however, appear to have been far lower than the initial reports of 3,000 dead or injured.
[ 19] Our results found larger correlations between the global measures of change with the present state (HRQoL) and far lower correlations with the initial state, supporting this hypothesis.
"An unspecified production problem at the iPad's manufacturer, Hon Hai Precision, will likely limit the launch region to the US and the number of units available to roughly 300K in the month of March," he writes, "far lower than the company's initial estimate of 1,000K units.
In reality, though, the costs for the minor review changes made to initial manuscripts is far lower, and the benefits are negligible.
To put it another way, General Motor 's Bob Lutz Bob Lutz recently whined to the media about how the reputation of his company's products was far lower than how the cars have actually surveyed in recent J.D. Power initial quality studies.
Under revised guidelines recently announced by the government, the cost of the Olympic stadium will be capped at 155bn yen, far lower than the most recent estimate of 250bn yen for Hadid's initial design.
The initial concentrations of some of the metals present were also far lower than others, in the order of tens, to hundreds and even thousands of micrograms.
The cost of the Immunochip is far lower than GWAS chips (~US$39/sample) because it has been produced in very large numbers ( > 150,000 ordered in the initial batch).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com