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Other vaccines are under development and some require far lower doses.
Nowadays workers are exposed to far lower doses and manganism is rare.
A commonly used tranquilizer is believed to cause fatal irregular heartbeats at far lower doses than expected, prompting the government to urge doctors to try other medications.
Today, menopause hormones are advised only for the treatment of moderate to severe hot flashes and other menopause symptoms, and doctors typically prescribe far lower doses of the drugs than those used in the study.
Today, menopause hormones are advised only for the treatment of moderate to severe hot flashes and other menopause symptoms, and doctors typically prescribe far lower doses of the drugs and in a form different from those used in the study.
Merck found that in some cases it needed far lower doses -- which usually means fewer side effects -- than if using the more typical criterion of how much the patients could tolerate, said Richard Hargreaves, the company's executive director for imaging.
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We hypothesized that successful vaccination could be achieved this way with far lower antigen doses than required by the needle and syringe.
Endocrinologists are concerned that these chemicals may be able to cause subtle health problems at doses far lower than the high doses toxicologists typically use to assess safety today.
38 In addition, research study by Ferris et al 39 proved that a higher dose of donepezil (23 mg) a day after 6 months had showed a 0.8-point improvement over the so far used lower dose (10 mg) of this drug.
In this case, it may be expected that at a dose far lower than the lowest tested dose levels, the effect will decrease again, because infinite toxicity cannot be observed at dose levels close to the zero dose.
In our study, we utilized a dose of 1 mg/kg body weight/d, a dose far lower than the reported maximum safe dose and one that has been previously tolerated without side effects (24 – 24).
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