We found that Nup98 FG domains assemble from (even dilute) aqueous solutions into very protein-rich phases that reject inert molecules ≥25 kDa in size, but at the same time allow influx of far larger NTR-complexes.
Much to our surprise, however, we observed that a far larger ≈530 kDa complex, namely a complex comprising four Importin β molecules and an IBB-ZsGreen tetramer, crossed the buffer-particle boundary efficiently and accumulated strongly inside.
They depicted individuals trying to cope with far larger and more complex forces and systems.
In many cases, companies choose peers that are far larger or more complex and whose executives are paid more to manage that size and complexity.
WASHINGTON — Fresh from pushing Chrysler into bankruptcy, President Obama and his economic team are hoping that the hard line they took last week gives them leverage to force huge changes in General Motors, a far larger and more complex company.
Chrysler was openly acknowledged as a test drive for the bankruptcy of General Motors, a far larger and more complex company that is in the early stages of its case.
It typically takes six months to a year for a bank to set up an ordinary structured investment vehicle, but the so-called super-SIV, though far larger and more complex, was put together by the three banks in a matter of weeks with the encouragement of the Treasury Department.
But, the universe of potential acquirers is far larger and more complex than most realise.
As a research discipline, chemistry has itself evolved over the last few decades to focus its metaphorical microscope on both far larger and more complex molecular systems than previously attempted, as well as uncovering a far more subtle understanding of the quantum mechanical underpinnings of even the smallest of molecules.
Computers, of course, make it possible to test far larger and more complex problems.
