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Reporter assay demonstrated that SHIP1 was the most powerful promoter among all of the SHIPs and had far greater activity than the endogenous human insulin promoters and RIP in PDAC expressing PDX-1.
Like the nonpolar fractions, the semipolar aromatic fractions also exhibited far greater activity in the frame-shift strains (i.e., TA98 and YG1041), as compared to the base-pair substitution strains (i.e., TA100 and YG1042), with no activity observed in TA100 at all.
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"If we can get everyone speaking on the same page, we'll generate far greater field activity".
The untoward complication of continued use of fibrinolytic therapies can be bleeding if exogenous plasminogen activator activity is far greater than endogenous plasminogen activator inhibitor activity.
Next year's budget deficit, at around 11.6% of GDP, will be similar to this year's.The budget came against the background of a sharp contraction in economic activity, far greater than that experienced in other euro-area countries.
It also has a far greater component of criminal activity, primarily in the form of drug trafficking.
PEDF possesses potent anti-angiogenic activity, far greater than any other known anti-angiogenic factor [ 12], and it has anti-tumor properties including the ability to promote tumor differentiation and initiate apoptosis [ 13- 16].
It was later discovered that PEDF has potent anti-angiogenic activity, far greater than any other known endogenously produced inhibitors of angiogenesis, including angiostatin, endostatin and thrombospondin-1 [ 10].
But at a meeting on the future of combinatorial chemistry here yesterday, a chemist proposed a new way to boost the odds: pair the most promising building blocks to produce compounds whose activity is far greater than the sum of their parts.
Unsurprisingly, this value is far greater than the reported specific activity in a crude extract containing enhanced levels of S. enterica PduS [12].
Interestingly, relative to the native Hyd-5, the application of aerobic assay conditions had a far greater effect on the catalytic activity of both the H229A and E73A variants.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com