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Given the limitations of all therapeutic approaches so far explored to treat LSDs, looking for new strategies to optimize therapies and to target the diverse cellular and phenotypic aspects of these diseases is becoming an important goal of current research.
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Although this structural diversity has so far only been explored to a limited degree, it potentially couples NHC-like adaptability with carbanionic reactivity.
Indeed, it has been widely described that, in France, immigrants use health services less than French nationals on average, whether primary or specialized care [ 23, 24], but the reasons for not consulting a GP have been systematically explored to a far lesser extent, particularly in the area of mental health and more specifically in cases of depression.
So far, only exon skipping has been explored to treat CNS defects.
So far, two main strategies have been explored to create humanized CML models in immunodeficient mice.
To our knowledge, two published observational studies have so far explored the risk of thyroid cancer in association with use of metformin [ 6, 27].
Our Recognise Me campaign – headed up by Guest Editor Shon Faye – has so far explored the experience of people who transitioned young, running inclusive clubs and ways to be a trans ally.
An important modification to the original proposal is that, in the systems so far explored, the cleaved target is phage DNA itself rather than mRNA [ 39].
To the best of our knowledge, only one group has so far explored the option of distinguishing among nanoparticles by their shape (Meyer et al. 2005, 2010).
It has thus far explored mechanisms for central collection of clinical, pathological and radiological data on diagnostic parameters, treatment and outcomes linked to tumour material that could serve as a clinical research resource.
However, a few studies have thus far explored the underlying mechanism in humans.
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