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The high heritability of BD is well established; however, identified susceptibility genes have so far explained only a small proportion of the risk (McGuffin et al. 2003; Farmer et al. 2007; Gottesman et al. 2010).
In retrospect, Mont?far explained, Darwin?s interest in traveling the world on board of the HMS Beagle (1831?1836), and subsequent visit to the Galapagos Islands in 1835, was inspired by Alexander Von Humboldt?s Personal Narrative of Travels to the Equinoctial Regions of America (1799 1804), a recount of expeditions and scientific discoveries in pristine Caribbean and South American landscapes.
That's because a new water treatment plant is only hooked up to one side of the reserve so far, explained Orville Ncwatch, the reserve's water operator.
Nonetheless, CNVs have been implicated in only a few percent of the 2,000 or more Mendelian diseases so far explained at a molecular level.
Its inhibitory effect was so far explained by its resistance to RanGTP-mediated release from its high affinity binding sites at nuclear pores.
With only limited empirical data to guide future locus-discovery efforts, extrapolation from the modest proportion of genetic variance so far explained is fraught with danger.
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In 2013, Kingfisher published a paper on what it has learned so far, explaining the economic and sustainable business opportunities to its peers, government and NGOs.
Last week, Mr. Constâncio actually appeared to boast about the bank's restraint thus far, explaining to harried investors that the central bank's bond-buying effort represented about 2 percent of euro area G.D.P.
It was also surprisingly educational, with Paul Ritter's crumpled forensics expert Randolph (star of the show so far) explaining that every drug lab worth its salt has a 's**t button'.
"These figures bear out the fact that, in recessionary times, you can only cut costs so far," explains Dave Wilson, CEO of GMAC, talking from its headquarters in the USA.
However, there is no research so far explaining the relation between blood oxygenation and muscle fatigue directly.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com