Such data would serve to aid the understanding of relationships between the distribution of various amino acid residues in the protein molecule and the unique structure and/or functions of RNase A. This review summarizes the thus-far clarified roles of 38 of the total 124 amino acid residues which comprise RNase A, with respect to protein function, stability, and folding.
Although the mechanisms behind the association are far from clarified, both genetic and environmental factors seem to play a role.
The pathogenetic mechanism underlying focal sialoadenitis in HCV-infected patients has not so far been clarified.
However, the mechanisms of the interaction between cytokine, pain and depression are so far not clarified.
Thus, although it is sure that NFκB is activated in human and animal myocardium during remodelling, the relationship between heart and periphery is far from clarified.
Thus, there is evidence that autophagy may function as a mechanism behind hypoxia-induced metastasis, but its precise role is far from clarified.
Still, the pathogenesis of preeclampsia is far from clarified and it has even been suggested that early and late onset preeclampsia represent two different diseases [ 6, 7] It is well known that also cigarette smoking is associated with FGR.
While interference with the mechanisms underlying diffuse glioma growth may be exploited as a novel therapeutic approach, up till now the crucial prerequisites for this growth pattern are far from clarified.
Thus, there are some indications that certain aspects of the ward atmosphere may be related to the psychosocial work environment of the staff, but the relationship is far from clarified.
At the time being, it is far from clarified, whether these therapeutic aspects will be effective regarding cyst growth and preservation of renal function in patients with PKD or have influence on the abnormal urine concentrating and diluting ability in progressive renal disease.
