The story, which takes place over about two decades, is standard family evolution stuff, narrated in retrospect by the elder version of Reuben (Hill Harper).
Each gene family is color-coded to depict dynamics of gene family evolution.
Comparative analyses of eukaryotic genomes are providing insights into the mode and tempo of domain family evolution.
A good family design allows us not only to combine existing algorithms but also to easily incorporate new ones, improving software family evolution.
There are two puzzles in understanding of the DAZ family evolution.
Several methods have been described that assess the tempo of gene family evolution.
Previous analyses of conotoxin gene family evolution reveal that conotoxins are subject to very strong positive selection [2] [6].
For example we have studied the aldehyde dehydrogenase family evolution, structure and function with computationally intensive methods [29], [30], [31].
With the identification of human and mouse boule in addition to dazl and daz, Xu et al [15] proposed a model for the DAZ gene family evolution.
To ensure the robustness of our inferences of accelerated gene family evolution, we again identified families with P<0.0001 in Ensembl v39 and v32.
We showed that the medaka boule has a previously unidentified expression pattern, which may provide important implications on the DAZ gene family evolution and boule gene function.
