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If the disorder is categorised as "familial" (i.e., occurs more in families than by chance alone), which are usually very rare by nature, then availability of familial data becomes crucial, as unaffected members of the family are going to be the main source of information when determining neutral alleles.
These familial data indicate that this corresponds to the small but significant number of families in which Rb is inherited with incomplete penetrance (IP) [ 3].
We previously proposed to extend the principal component analysis to include familial data [18].
We recently proposed an extension of the method of Price et al. [6] to include familial data [36].
The extensions of PCA to familial data are also proposed by Zhu et al. [14] and by us previously [18].
A first phase of genotypic reconstruction is required, based principally on a combination of information from the familial data.
Similar(35)
Genomic sequencing of SNPs is increasingly prevalent, though the amount of familial information these data contain has not been quantified.
The genetic data associated with familial AD [ 6] strongly suggest that PS, APP and its proteolytic fragment Aβ are involved in AD disease progression but exactly how they contribute to both normal cognition and dementia is the focus of much debate.
The hereditary nature of genomic data may transform the personal decision of sharing genetic data into one with familial ramifications.
Similar critiques have been made that 23andMe is using its customers' bio-data and familial information to launch new business products.
Neither the proliferation nor the tubulin defects are due to the EBV transformation of the cell lines as many independent proliferation and tubulin polymerization assays performed on lymphoblastic cell lines derived from families with predispositions to various haematological malignancies do not show similar familial clustering (data not shown).
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