Sentence examples for false substrate from inspiring English sources

It acts as a false substrate for the aromatase enzyme and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as suicide inhibition (Dowsett 1998).

Previously, we had used guinea pigs with chronic allergic inflammation treated with a false substrate for all NOS (L-NAME) and a specific iNOS inhibitor (1400 W) to demonstrate that all NOS constitutive isoforms reduced lung responsiveness and inflammatory response and protected against extracellular matrix remodeling.

FA analogues act as false substrates or inhibitors of FA metabolism, and many PET FA analogue tracers have been designed to reflect myocardial β-oxidation.

My argument is that the key selective advantage was expansion of the digestion chamber volume and associated reduction in accessibility of the proteolytic site to false substrates.

L-arginine analogues, such as Ng-nitro-L-arginine methyl ester (L-NAME), act as false substrates and are selective inhibitors of NO synthesis.

After intracellular phosphorylation, NIs like mericitabine (R7128) or sofosbuvir (GS-7977) get incorporated into the growing RNA chain as false substrates, which causes direct chain termination.

Here, since we are looking for compounds that are not transported by BCRP (BCRP nonsubstrates) and we want to discard BCRP substrates, the previous expressions may be re-written as follows: (3) Se = True    nonsubstrates True nonsubstratestes + False    substrates, Sp = True    substrates True substratestes + False    nonsubstrates.

The ubiquitin machinery, particularly the ubiquitin E1 UBE1, can utilize highly overexpressed NEDD8, causing "false" neddylation of substrates (Hjerpe et al., 2012).

When Scansite was run on our random sequence database, 2.8% of the sequences were detected as candidate Cdk substrates -a false positive rate of 67% for Scansite, for Cdk substrate prediction in this dataset.

The idea that living organisms are algorithms helps perpetuate the false notion that the substrates of organism construction are not relevant.

Using event-related potential studies investigating the neural substrates of false belief reasoning revealed a specific late negative component which could be located in the middle cingulate cortex, which may be related to conflict or error detection (Wang et al. 2008).