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The fact that S100A6 is elaborated by a number of human cancers, suggests that its use as a sole biomarker may encounter potential false positive incidences, akin to CA-125.
With a false-positive incidence of 1.5%, a sample size of 1800 would yield a 95% CI for specificity of 97.9 99.0 [6].
If we observed a false-positive incidence ≥1.5%, the test would not meet FDA specificity requirements and there would be sufficient false-positives for us to proceed with the case-control study.
Naturally, this will also lead to a higher incidence of false positive annotation.
Associated with this is a substantial reduction in the predicted incidence of false positive and false negative results.
This allows early commencement of salvage therapy but a high incidence of false positive results was also recorded (17%).
This procedure reduces the incidence of false positive associations, although it might also reduce power to detect true positives of exceptionally large effect.
This software uses a density histogram of p values to calculate the incidence of false positive results for p values less than or equal to a given value.
Choosing a cavitated carious lesion, i.e. a stricter criterion for the disease detection, reduces the incidence of false positive findings.
Generally hCG measurements give an accurate insight into the response of gestational and germ cell tumours to treatment with a very low incidence of false positive elevations.
Polymorphisms result in a high incidence of false positive and false negative results in hybridization based analyses and hinder the identification of the true variation underlying genetically determined differences in physiology and behavior.
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CEO of Professional Science Editing for Scientists @ prosciediting.com