Exact(5)
The Bloom filters were created using a false positive frequency <0.05%.
For characteristics that were independently associated with atherosclerosis, sensitivity versus false positive frequency (1-specificity) for predicting plaque presence was analyzed employing receiver operating characteristic (ROC) curves.
Identification of 4/128 genes associated with survival in IDH wt gliomas is therefore within the range of the false positive frequency (1-12 %).
As this usually indicates a mapping artifact, we have added an optional filter which requires each reported candidate variant to be supported by at least one read in each direction in order to reduce our false positive frequency.
The sensitivity and specificity of the filter is very dependent on the reference filter size, the K-mer size, the match cut-off and the Bloom filter false positive frequency.
Similar(55)
Thus, such false-positive frequency is not transferable to the whole array.
This value represents a ceiling on the false-positive frequency, because LD is still inflating our estimate.
In our experience, visual selection of peaks using aggregate Manhattan plots reduces the effective false-positive frequency to <1 per 30,000 markers.
Sensitivity versus the false-positive frequency (1-specificity) for predicting radiographic disease progression (∆SHS ≥1 or ≥5) with adipokines levels and with other markers of radiographic disease progression (that is, DAS28 value, number of swollen joints, CRP level, RF level, and anti-CCP antibodies level) was analyzed with a receiver-operated characteristic (ROC) curve.
The compensatory increase in false-positive frequencies is often relatively small.
For example, only one of the multiple tests within the evaluation criteria for ruling in hormetic response and ruling out false-positive frequencies in Tables 4 and 5 and Figure 2 of Calabrese and Baldwin (2001) is the statistically accepted one of statistical significance (p ≤ 0.05).
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