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Such a high false negative frequency will prevent the timely diagnosis of ESCC for some patients, particularly the symptomless, early-stage patients.
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As expected, in many tested scenarios the false-negative frequency declines with a reduced p-value threshold (Table 1).
Here, we define false negative as the frequency at which individuals heterozygous or homozygous for the variant alleles are incorrectly called as homozygous for the reference allele.
Logistic models of the sensitivity dependence of DDiMAP on variant frequency at 400 and 800 ppm thresholds show that DDiMAP (blue) can identify low frequency variants below the VarScan2 hard threshold (green) with an acceptable trade-off between lower frequency true positive calls and higher frequency false negative calls.
For example, KOG provides a low false negative rate (but high frequency of false positives), while RIO offers the reverse.
GoodNotes shows a low frequency of False Negative strokes.
However, a high frequency of false negative muscle biopsies has been reported, which might be due to the patchy nature of IIM.
Here we attempt to reduce the frequency of false negative ER status classification using two gene expression approaches and compare these methods to IHC based ER status in terms of predictive and prognostic concordance with clinical outcome.
Minimising the frequency of false negative ER status classification is essential to identify all patients with ER positive breast cancers who should be offered endocrine therapies in order to improve clinical outcome.
Yeast two-hybrid analyses typically suffer from a high frequency of false negative results and this may be a particular problem when dealing with very insoluble proteins such as PFR components.
Thus, with the proposed alternative scoring method the frequency of false negative BAC coordinates was very much reduced.
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