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This was done to avoid false linkages from the expected Mendelian segregation ratio.
False linkages would likely have dissimilar injury characteristics, artificially lowering coding agreement.
As many turning points and false linkages were considered, these contigs were manually assembled by the following criteria.
628 records had differing CHI numbers, and are therefore potential false linkages from our type of probability linkage.
These were excluded from further analyses due to their tendency to introduce false linkages into the analysis.
Markers that were distorted significantly with P < 0.0001 were not considered because ratios that are too skewed might create inaccurate distances and false linkages (Cervera et al. 2001).
Similar(47)
The 234 distorted markers were excluded from the linkage analysis because they could lead to false linkage between some markers or linkage groups.
Apart from 4 mismatches where the mothers had stated totals that were different from the detailed information given that were possibly due to entry errors, most (127 births) were likely to be "false positive" linkages, as reflected by their median linkage score of 24.
We identified a small number of hospital admissions and ED presentations which could not be reconciled with the date of death, which if considered to be false positive linkages would equate to <0.1%% false positive linkages between the death data and hospital or ED records.
In addition, this study was retrospective, relying upon linkage with routinely collected administrative data, and some false-positive and false-negative linkages do occur.
These filters therefore remove false positive linkages derived from experimental noise and drift in otherwise unchanging baseline expression levels.
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