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This increase in space increases the number of interacting pharmacophores, thereby increasing the chance of false interactions.
We used only human interactions, eliminated the support_type = FALSE interactions and mapped by the HGNC column.
True and false interactions were classified manually by experts.
At the same time about 15% false interactions are predicted.
This means that bottleneck information were effective in dense network which may include many false interactions.
Firstly PPI data descending from high-throughput techniques suffers from many false interactions [ 49].
Similar(28)
We performed the evaluation on simulated data, where false positive interactions are known, and on false interaction-imputed GEO data sets.
We labeled an interaction 'T' (for possible True interaction) if it has two or more 'P' labels; otherwise it was labeled as 'F' (for possible False interaction).
Text-mining is not able to eliminate the selection of false interaction pairs; in the case of LAITOR (contained in the PESCADOR platform), the type 3 and 4 interactions can present genes with no association specified in the text [ 20].
We found that for a set of simulated and false interaction-imputed experimental data sets, the utility of replication groups as described by Gayan et al. (2008) does not improve upon the direct scoring of SNP interactions.
All genes were mapped to the official gene symbol using HUGO Gene Nomenclature Committee (HGNC) [ 29] to avoid false interaction to same genes/proteins and the data curation was carried out using Microsoft Excel and Microsoft Access.
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