It appeared to the pilot that the aircraft was close to the dynamic equilibrium he wanted, needing only small adjustments, when it was actually in a dangerous false balance.
This leads to an apparent excess of heterozygotes that inflates the number of false positives in Hardy Weinberg equilibrium tests.
In addition, given that the chromosomes in our F2 population were in linkage equilibrium, only one false positive might be expected over the entire genome of 20 chromosomes.
A common protocol was used to perform quality control of the genotype data in both cohorts using the GenABEL package (54) implemented in R (http://www.r-project.org/): individual call rate at 97%, SNP call rate at 95%, minor allele frequency at 2%, P-value for deviation from Hardy Weinberg equilibrium at 1.0E−10, false discovery rate for unacceptably high individual heterozygosity at 0.01.
CI: confidence interval; FPRP: false-positive report probability; HWE: Hardy Weinberg equilibrium; Kbp: kilobasepairs; OR: odds ratio; SNP: single nucleotide polymorphism.
BMD = bone mineral density; BMI = body mass index; CI = confidence interval; EM = expectation-maximisation; ESR1 = oestrogen receptor α gene; FPRP = false positive report probability; HWE = Hardy Weinberg equilibrium; OR = odds ratio; PCR = polymerase chain reaction; SNP = single-nucleotide polymorphism.
Not only do emotions disturb the equilibrium of the soul and impede constancy, they are false and dangerous, since they can upset the detachment needed by the wise man(sapiens).
Indeed, as we carried out as many tests as there were combinations for the Hardy-Weinberg test of equilibrium, (i.e. 162), we had to control for false positives.
This reflective equilibrium is susceptible to bias when methodologically bad and hence false or potentially misleading empirical information is taken into consideration.
