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The algorithm provides a principled statistical approach for hit identification and false discovery rate control.
Adjustments made to alpha levels (e.g., Bonferroni correction) or other procedure used to account for multiple testing (e.g., false discovery rate control) should be reported.
To identify unigenes with a statistical difference in transcript abundance, we used a method described in [30] based upon the frequencies which genes occur in each library and false discovery rate control for multiple test corrections [31].
False Discovery Rate control [ 23] was used to account for multiple testing (q < 0.2).
Third, a target-decoy strategy is used for false discovery rate control.
False discovery rate control procedure is implemented to adjust P-values for multiple testing.
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Yekutieli, D. & Benjamini, Y. Resampling-based false discovery rate controlling multiple test procedures for correlated test statistics.
p value adjustment was performed using the false discovery rate controlling procedure [ 90].
P-values were calculated under this assumption, and adjusted for multiple testing using the false discovery rate controlling procedure.
It supports any statistical test that is based on contingency tables, and enables both family-wise error rate and false discovery rate controlling.
We applied more than one database searching algorithm and practiced stringent false discovery rate controlling when testing our database with lung cancer mass spectrometry data.
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