Our assumption that these costs are not large is made to render the mathematical analysis tractable, but fairly small values such as, have been considered appropriate in other modeling studies (Tabashnik et al. 2008, Supplementary Information).
In addition, H186 in helix 2 displays a fairly small S2 value and a much lower J 0) value after the I214V mutation (Fig. 5 and 6), implying prominent internal motions which potentially make a significant contribution to destabilization of helix 2. Thus, it could be expected that the conformational change is somewhat easier to occur for the I214V mutant than for the wild-type.
However, the residue H186 in helix 2 displays a fairly small J 0) value, implying significant internal motion on the ps-ns time scale.
H186 in helix 2 shows a fairly small S2 value as low as 0.56, indicative of significant internal flexibility incompatible with the secondary structure property.
Even so, the gap between home values in this zip code and the rest of Anchorage is fairly small: Home values are only 52percentt higher within the 99516 ip code.
Fairly small rmsd values were observed for the other four mutants (Y279C, T468M, Q506P, and Q510E), suggesting that these mutations cause no obvious structural alterations in the overall structures.
This can be seen from comparing the structures of lc apo DHFR and its ternary complex DHFR.TMP.NADPH where superimposition of each individual helix results in fairly small rmsd values (for helices C, E, and F the RMSDs are 0.18, 0.12, and 0.11 Å, respectively).
When the starting tree does not distort evolutionary distances at all, the padded set should contain all the short quartets (even for fairly small p); thus, small values for p should suffice when the starting tree has only small distortion.
However, there is a well-defined but fairly small signal with minimum values at the equator.
Nevertheless, in all instances, RERI values are fairly small and the 95% CIs cover the null values of RERI, suggesting that the GRS and the conventional risk factors do not have effects beyond additivity.
The change in the percentage of off-target effects induced by restricting K B values was fairly small compared to the change induced when other model parameter values were restricted.
