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To ensure complete inhibition of all ELR+ CXC chemokines present in circulation, we used fairly high doses of our engineered antibody fusions (50 mg kg−1).
Yet nitrogen oxides are not particularly dangerous and can be given in fairly high doses to men and women without serious effects, said Anthony Frew, professor of allergy and respiratory medicine, at the Royal Sussex County Hospital.
But, largely due to a lack of data, the consequences of smaller doses are more controversial.Much of the information on the health effects of radiation comes from studies on survivors of the Hiroshima and Nagasaki nuclear-bomb attacks, most of whom received fairly high doses.
"Hookah delivers fairly high doses of nicotine but very high doses of carbon monoxide," Dr. Kenneth D. Ward told VICE in an email.
But Frye was dealing with young, healthy teens who became very sick in days; only fairly high doses of listeria would give them the high fevers, diarrhea and vomiting they developed.
While many people exposed at Hiroshima and Nagasaki received fairly high doses, the recommended occupational and environmental dose limits aim to control the risks from much lower doses.
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The latter was most likely attributable to the fairly high dose of cisplatin (100 mg m−2), which was administered at the two highest dose levels.
The results from this study demonstrated that kava when administered alone via gavage in C57BL/6 mice induced no adverse effect even at a fairly high dose (500 mg/kg bodyweight daily) in a chronic manner, as reflected in mouse growth and serum levels of ALT and AST.
That work is inside the structure and that is fairly high-dose and will require a lot of workers to execute.
When the dose of crack was fairly high, the subject would typically choose to keep smoking crack during the day.
"We hate to throw the baby out with the bathwater — they do work for some people — but it is fairly high risk when these drugs are given in moderate to high doses, especially when given over time.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com