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The latter was most likely attributable to the fairly high dose of cisplatin (100 mg m−2), which was administered at the two highest dose levels.
The results from this study demonstrated that kava when administered alone via gavage in C57BL/6 mice induced no adverse effect even at a fairly high dose (500 mg/kg bodyweight daily) in a chronic manner, as reflected in mouse growth and serum levels of ALT and AST.
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But, largely due to a lack of data, the consequences of smaller doses are more controversial.Much of the information on the health effects of radiation comes from studies on survivors of the Hiroshima and Nagasaki nuclear-bomb attacks, most of whom received fairly high doses.
"Hookah delivers fairly high doses of nicotine but very high doses of carbon monoxide," Dr. Kenneth D. Ward told VICE in an email.
While many people exposed at Hiroshima and Nagasaki received fairly high doses, the recommended occupational and environmental dose limits aim to control the risks from much lower doses.
After 48 hours' exposure to fairly high doses of fullerenes, the fish probably had the same effect as a very bad headache, she says, but they did survive the exposure.
Fairly high doses (400mg) of vitamin B2, also known as riboflavin, may help prevent migraines.
Certain vegetable oils contain fairly high doses of ALA, a type of omega-3 fatty acid that your body can partially convert into DHA.
That work is inside the structure and that is fairly high-dose and will require a lot of workers to execute.
When the dose of crack was fairly high, the subject would typically choose to keep smoking crack during the day.
"We hate to throw the baby out with the bathwater — they do work for some people — but it is fairly high risk when these drugs are given in moderate to high doses, especially when given over time.
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