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Full-length A-RIFIN and B-RIFIN proteins are easily recognized, upon visual inspection of multiple sequence alignments, based on the presence (A-RIFIN) or absence (B-RIFIN) of a fairly conserved 25 amino acid residue indel in the conserved region.
The HMG domain of SOX2 remains fairly conserved between homo sapiens, Mus musculus and Danio rerio (Swiss-Prot: P48431, P48432, Q6P0E1).
Numerous instances can be seen in evolution in which protein quaternary structures have diverged while the sequences of the building blocks have remained fairly conserved.
The broadly neutralizing antibody 2G12 binds a fairly conserved cluster of oligomannose sugars on the HIV surface glycoprotein gp120, which has led to the hypothesis that these sugars pose potential vaccine targets.
Thus, overall, although putative pro-enzyme and putative enzyme domains seem fairly conserved, the extent of variation in variable domains 1 and 2 differs greatly among parasite lineages.
Further these "false positives" were found to be fairly conserved in the course of evolution (data not shown) reinforcing the important role of these residues in the formation of protein-protein interaction interface.
Similar(19)
These Grs are fairly easily recognized through their somewhat conserved TM7 regions near the C-terminus, which includes a TYhhhhhQF motif in TM7.
These gene sets were used on our chicken gene expression data because they included not only transcription factor binding site, but also miRNA binding sites, which are fairly well conserved between species [42].
These sequences are fairly well conserved in the Tiam1/2 PH subdomains.
In A. thaliana, there are seven genes encoding the BCATs, and it is known to be fairly well conserved [ 40].
The framework regions of antibodies are fairly well conserved, while the structural variations occur mostly in the CDR loops.
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