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At the least, it may account for some failures to replicate results in animal experiments, a perennial problem in the field.
"Failures to replicate and reproduce findings should be considered a normal part of science".
The three failures to replicate seem to be due to the experiments themselves: The effects may just not be real.
That means 1 out of 20 findings is deceptively spurious, luring scientists down twisted paths lined with failures to replicate, wasted money, and lost time.
A small number of candidate genes (e.g., GABRA2, MAOA, SLC6A4, AVPR1A) are associated with CD related phenotypes across independent studies; however, failures to replicate also exist.
Furthermore, failures to replicate still occur even when a statistically conservative multistage approach is used.
Similar(47)
For years, it was extremely difficult to publish a direct replication, or a failure to replicate an experiment, in a good journal.
"It's almost impossible to publish a failure to replicate," said Mr. Simons, who is working to start a journal dedicated to replication studies.
We proposed a model to explain these observations in which failure to replicate G4 motifs in a timely manner leads to uncoupling of the replicative DNA helicase and DNA polymerase resulting in the formation of post-replicative gaps.
In 2004, Schooler embarked on an ironic imitation of Rhine's research: he tried to replicate this failure to replicate.
In isolation, a single failure to replicate doesn't tell you that much.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com