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That has resulted in more frequent failures of standard antibiotic treatment for chest infections.
A retrospective case review of 69 CD patients (failures of standard as well as two anti-TNF-α therapies) treated with natalizumab at six sites in Massachusetts, USA, showed that 69% had a partial or complete clinical response.
5 In recent years, biologic agents have been introduced for use in CD and UC patients who failed conventional therapy in the "step-up" approach (standard therapy given first, and biologics for the failures of standard therapy) and as a first-line agent for CD patients with fistulae.
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And that scepticism was greatly reinforced by a total failure of standard economic models based on efficient financial markets to anticipate the last disaster.
According to his notion, the failure of standard quantum mechanics to predict the behavior of individual atoms arises from the fact that it does not take into account the vast numbers of interconnections extending across the universe.
After the failure of standard first-line cisplatin/antifolate chemotherapy, there is no accepted treatment.
Lucas (1990) stressed the failure of standard neoclassical growth models to explain the movement of international capital flows.
Microvascular decompression is a second-line treatment after failure of standard medical treatment with high success in glossopharyngeal neuralgia.
The presented data support MVD on the basis of image processing as a safe and promising second-line treatment after failure of standard medical treatment or unacceptable side effects of drug therapy.
While it is possible that in some settings co-occurrence of resistance and host factors associated with reduced disease duration (i.e. HIV infection) may actually lead to shorter average durations of disease for those with DR TB, in most situations the DR phenotype will result in failure of standard treatments and a protracted disease course.
However, failure of standard anti-tuberculosis agents is strongly suggestive of NTM infection.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com