Such variability may explain, at least in part, the failure in translating many advances in basic science to clinical practice and why we have to face so many negative results in large sepsis multicenter randomized clinical trials [ 15].
Finally, although MCAK-depleted cells recruit astrin/SKAP to lateral kinetochores, the displacement of the microtubule end and the kinetochore is asynchronous, confirming a failure in translating microtubule changes into kinetochore movement.
As the extent of inhibition depends on the nature of inhibition (competitive, uncompetitive, mixed), the current technology can also be exploited to choose the most effective class of inhibitors and, to a certain extent, reduce the chances of failure in translating nanomolar enzyme potencies into MICs.
As such, it is not surprising that the biomedical field has encountered unprecedented failure rates in translating hard-earned discoveries into clinical progress.
The failure to date in translating identified effective clinical interventions into routine practice represents the gap between what is avoidable or preventable via these interventions and what is achieved in practice.
Many of the failures we have seen in translating novel basic biological discoveries to useful medicines are a result of the inadequacies of the animal models we use at the critical juncture between bench and bedside.
Although this could arise when education levels are low as witnessed in this study, it also points to a possible failure in translating relevant human rights tools to communities in the country.
Unfortunately, as discussed later in this review, there is a long history of failure in translating promising findings from preclinical animal models to clinical success, especially for neurological disorders.
The increased risk of final vascular access failure in women translated into a trend towards a lower long-term prevalent AVF use rate in female patients.
"One of the main causes for past failures of translated fiction to emerge as the winner in the MBI has been the absence of cultural transmission at this level.
Second, there is the frequent failure to translate results in non-human animals to parallel results in humans in the clinic.
