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Patients presenting obstructive acute renal failures, assessed by echography, were also excluded.
The impact of organ failures, assessed by maximum SOFA score, tended to decrease over time.
Moreno et al. reported in 1999 that the initial SOFA score could be used to quantify the degree of organ dysfunction or failure at admission and that there was a good correlation between organ failures assessed by the maximum SOFA score and mortality [ 29].
In multivariate analysis only comorbidities assessed by the Charlson index [Adjusted Odds Ratio, 1.6; 95% CI, 1.2-2.2; p < 0.003] and the number of organ failures assessed by the SOFA score [Adjusted Odds Ratio, 2.5; 95% CI, 1.1-5.2; p < 0.02] were independently associated with 3-month mortality.
Similar(56)
The evolution of organ failure assessed by SOFA score was similar between groups: 34% of patients were considered to be early SOFA-responders in the treated group, and 19% in the control group.
The evolution of organ failure assessed by the SOFA score was significantly different in survivors and non-survivors.
Some studies focused on the development of respiratory failure, assessed by physiologic and immunologic variables, or the duration of mechanical ventilation (MV).
Our results support the finding that prolonged tissue perfusion failure, assessed by hyperlactatemia and metabolic acidosis, is associated with the development of more severe organ dysfunction and death.
Variables considered for the analysis included, demographic data, co-morbidities, SAPS II score on admission, type of microorganism, organ failure assessed by the SOFA score.
The correlation between organ failure, assessed by MODS, and systemic inflammation, assessed by CRP, suggests that a good clinical course is associated with resolution of the inflammatory process whereas a clinical deterioration is associated with ongoing inflammation [ 33- 35].
Organ failure assessed by the SOFA score also showed a clear separation of costs at SOFA score < 7 (n = 369, €728 ± 240) versus SOFA score ≥ 7 (n = 84, €1,061 ± 402) (P < 0.0001).
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