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In CIZ1 null fibroblasts, failure to internalize is accompanied by the loss of PRC1/2-mediated modification of Xi chromatin, and relaxation of control over PRC1/2 target genes across the genome.
The INCS reflects "failure to internalize societal norms, lack of empathy for the pain of others, and an unrestrained yielding to impulse and self-gratification" and was originally designed to assess psychosis proneness.
Imperfect capital markets, which includes failure to internalize all costs of conventional energy (e.g., effects of air pollution, risk of supply disruption) and failure to internalize all benefits of renewable energy (e.g., cleaner air, energy security).
A failure to internalize guidelines into clinical routines was also identified as a barrier to guideline implementation.
Alternatively the C73R mutation might instead abolish a Golgi retrieval signal, resulting in failure to internalize TNFR1 and return it to the Golgi storage pool.
In addition, failure to internalize TNFR1 receptors is also likely to be further compounded by the activation of anti-apoptotic c-Rel NF-κB subunits [ 47].
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It is speculated that this may reflect defective killing of the organism by failure either to internalize the pathogen or to effectively initiate intracellular killing.
Therefore, we hypothesized the failure of aripiprazole to internalize D2Rs would reduce the likelihood of D2R downregulation and would therefore not produce a sensitized locomotor response to acute cocaine exposure.
Unfortunately, women, unlike men, tend to internalize "failure" and struggle with recovering quickly and moving on effectively.
It can make her more risk-averse and less self-promoting than her male peers, which can hurt her future success". It's very well documented that girls and women are more likely to internalize failure and mistakes while boys and men are more likely to externalize these.
Like so many other users, I have begun to internalize its failures and accept them as standard operating procedure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com