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We identified variants in the CC domain with intermediate effects in transcription that correlate with failure to interact with the PALB2 protein (Figure 3).
For primates, including humans, failure to interact leads inexorably to a decline in relationship quality, and a consequent loss of the benefits that derive from individual relationships.
How entitled can you be, for one, to think your redundant experiences or the failure to interact sincerely with the people around you warrants a short story, let alone enough short stories to necessitate a book?
This is explained by its failure to interact with RhoGDIα.
The loss of function of deleted/mutated PfI2 observed above may be related to its failure to interact with PfPP1.
This result supports the idea that failure to interact with S-PCNA yields longer conversion tracts, a feature not observed in the helicase-dead mutant.
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The frequent failures to interact with the robot via the voice control frustrated participants, even though they understood that the robot was only an imperfect prototype.
Failure to appropriately interact with anyone on Duke premises (including patients, their families, students, visitors, customers or other employees), when such behavior violates another's privacy or dignity, including sexual harassment.
The mechanism involved failure of APC to interact with the cytoplasmic domain of the α3 integrin, to stabilize focal adhesions and activate integrin-linked kinase-1 and phospho Akt.
Given the well-known role of WD40 domains in protein-protein interactions, one effect of the ΔWD truncation could be the failure of LRRK2 to interact normally with binding partners.
Indeed, mutations in Fln genes (A and B) cause a wide range of brain, bone, skeleton and heart developmental malformations, likely due to severe defects in embryonic cell migration as well as to the failure of Fln to interact with other proteins [8].
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