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In contrast with PERK, the ability of miR-PKR to increase Env expression in vitro did not translate into increased immunogenicity, presumably reflecting a failure to augment antigen expression or presentation in vivo.
However, subjects who maintained NGT exhibited a compensatory increase in insulin secretion, whereas failure to augment insulin release led to IGT, or overt diabetes (8).
Failure to augment expiratory flow after application of negative pressure to the airway circuit suggests airflow limitation, which usually occurs in the distal airways.
The negative expiratory pressure technique applies negative pressure to the expiratory circuit during exhalation, and failure to augment expiratory flow during this maneuver suggests flow limitation.
It is not known, however, if this represents a failure to augment maximally stimulated nitric oxide (NO) bioactivity or an absolute reduction in NO generation by the DM metabolic milieu in women compared with men.
A prior trial suggested that failure to augment serum cortisol by 9 μg/dl after high-dose adrenocorticotropic hormone (ACTH) was a bad prognostic sign and was independent of the pre-ACTH stimulated cortisol value [ 9].
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The failure of VIP to augment macrophage IL-10 production, unlike the murine system, is likely to result from the lack of activation/phosphorylation of CREB, a transcription factor that is readily activated in the murine system by VIP [ 10].
Cell-based therapies for liver failure offer the potential to augment or replace whole organ transplantation.
High-resolution finite element models of trabecular bone failure could be used to augment current techniques for measuring damage in trabecular bone.
Tissue-engineered therapies for liver failure offer the potential to augment or replace whole organ transplantation; however, fabrication of hepatic tissue poses unique challenges largely stemming from the complexity of liver structure and function.
The group subsequently reported that failure of PARL shRNA to augment FL-PINK1 accumulation indicated that PARL was not required for PINK1 processing.
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