Indeed, the progressive accumulation of polyubiquitinated protein conjugates, indicating a failure of proteasomal turnover, is a consistent feature of many neurodegenerative diseases [ 44], including ALS [ 1].
Mice deficient in membrane type 1-MMP were found to have a severe phenotype, with the failure to turnover collagen at crucial stages of development apparently important [ 106].
Impressive displays of physical skill, but plays with a far greater chance of failure, turnover and injury.
With long histories of failure and constant turnover of teachers, the prevailing wisdom goes, these schools cannot afford to abide misspellings or other errors that in wealthier, more successful schools might be considered normal in young children and even endearing.
After failure of outreach service, bed turnover was similar (2.29 to 2.3).
Fibrosis occurs as progressive liver accumulation of proteoglycans, glycoproteins, and collagens with predominance of types I and III fibrillar collagens and failure of physiological mechanisms of matrix turnover.
Scar accumulation is the result of a bidirectional process combining increased synthesis and deposition of extracellular matrix proteins within the liver, and a parallel failure of physiological mechanisms underlying matrix turnover [ 1, 2].
Sitting next to her best friend, co-host Gayle King, Oprah didn't flinch from the grim realities of OWN, which has seen low ratings, constant turnover, and the failure of Rosie O'Donnell's talk show.
The second step reveals that failure in turn has a positive impact on performance in term of percentage of turnover from new to the market innovative products.
The Royal Blues have become specialists in failure under Heldt; the banal but devastating failure to use their considerable resources – they are the 13th richest club in Europe in terms of turnover – in a competent manner.
Any of 3 parameters can be used in making this determination: continuing loss of bone mass on therapy, failure of therapy to suppress biomarkers of bone turnover, or the occurrence of additional fractures on therapy.
