There may be publication bias of topical NSAID trials, the failure of small trials that show no effect to be published [ 59].
The failure to know whether treatments that don't work over all might help some patients is not a failure of clinical trials, but rather reflects our limited biologic understanding, the focus of basic research.
The failure of these trials promoted a shift to the development of HIV vaccines for eliciting T cell responses.
Our study uncovers the molecular heterogeneity of SLE and provides an explanation for the failure of clinical trials.
Because of the failure of both trials, the scheme was not rolled out to other parts of England as many of the policy's supporters had hoped.
The failure of recent trials to prevent further cognitive decline in patients with mild to moderate Alzheimer's disease has been partly put down to timing.
There are numerous explanations for the failure of these trials, including ineffective interventions, inadequate sample size, treatment side effects, and insensitive or inappropriate outcome measures.
With the failure of these trials to demonstrate protection, the focus for HIV vaccine development has shifted to inducing a cytotoxic T-lymphocyte response (CTL).
Failure of clinical trials of nonviral vector-mediated gene therapy arises primarily from either an insufficient transgene expression level or immunostimulation concerns caused by the genetic information carrier (e.g., bacteria-generated, double-stranded DNA (dsDNA)).
