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"It is like trying to fit a saddle on a cow". By the time Colonel Tsaglov put pen to paper, Mikhail Gorbachev, shocked by the failure of the intervention and increasing public anger at Russian losses, had already decided to pull out.
The persistence of infection, pain or immobility was considered as a failure of the intervention.
It is unlikely that failure of the intervention reflects a pharmacokinetic limitation.
Several factors may have contributed to the failure of the intervention.
Therefore the significance of a failure of the intervention to prevent PND is difficult to interpret.
In addition, it is important to conduct a process evaluation to explain the success or failure of the intervention.
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The lack of effect may reflect the failure of the interventions to address some of the barriers to healthy weight gain identified in the qualitative studies.
Being a cluster-randomised complex intervention, a process evaluation nested inside the trial was started in order to clarify causal mechanisms and to identify obstacles or other contextual factors contributing to the variation, success, or failure of the interventions [ 25].
On the light of this data, we believe that orthognathic surgery should not be a procedure to adopt in case of failure of the interventions of Phase I, but this should be the first choice, especially in cases with documented dental-skeletal malformations.
Thus, we are more likely to capture both successes and failures of the intervention.
For example, a process evaluation can shed light on: (1) whether the intervention was delivered as intended (i.e. compliance, satisfactions, and experiences); and (2) the success and failures of the intervention program [ 14- 16].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com