Sentence examples for failure of the checkpoint from inspiring English sources

Because they do not arrest in G2/M it appears that PXD101 does not induce this checkpoint in the resistant cells., However, in combination with drugs that can, PXD101 may cause the failure of the checkpoint and induce apoptosis.

Failure of these checkpoint responses leads to a build up of harmful mutations.

Failure of the spindle assembly checkpoint results in gain and loss of chromosomes, or aneuploidy, a condition associated with malignancy and birth defects.

The overexpression of PLK-1 is actively implicated in the failure of mitotic checkpoint arrest and tumor progression.

We showed that impaired Brca1 function causes chromosome damages, failure of the G2/M cell cycle checkpoint, and centrosome amplification, leading to p53-dependent lethality.

Zhou and collaborators speculate that unfolded p53 might be the responsible for the failure of G1/S transition checkpoint in AD lymphocytes, which is normally mediated by wt53, connecting unfolded p53 to a peripheral event associated to the disease.

The failure of this control checkpoint may lead to genomic instability resulting in hypersensitivity to radiation.

At 24 h after irradiation, XRCC4 m/m cells in G1 phase were 93.91 ± 0.33% and those in G2/M were unchanged (5.44 ± 0.77%), probably because of failure of G2 checkpoint activation.

This is due to the intimate link between biorientation and checkpoint signaling: an apparent failure to silence the checkpoint could be caused by prolonged checkpoint activation if defective kinetochore-microtubule interactions persist.

We observed that such inadequate sequences of state transitions can cause a significant failure of the budding yeast cell cycle by violating the M phase checkpoint conditions.

Indeed, small residual amounts (2 5%) of the checkpoint kinase Bub1 are compatible with a checkpoint response in nocodazole, whereas its full depletion causes checkpoint failure (Meraldi and Sorger, 2005; Perera et al, 2007).