The Sustained Attention to Response Task (SART) is a widely used tool in cognitive neuroscience increasingly employed to identify brain regions associated with failures of sustained attention.
Last, there's the depressive inertia that flows out of sustained failure at the keyboard and infects the rest of life with grey minimalism, making it harder to answer letters, return library books, bother to cook meals not composed of pasta.
Tumour cell phenotype has six hallmarks: disregarding signals for growth arrest; failure to differentiate; capacity of sustained proliferation; evasion of apoptosis; ability of invasion; and enhanced angiogenesis (Bishop, 1987; Compagni and Christofori, 2000).
The consequences of failure to sustain and increase investments are straightforward for all three diseases.
At the end of the trial, the judge, Mr Justice Mackay, said that, in his 30 years in the legal profession, he regarded Balfour Beatty's failure as the "worst example of sustained industrial negligence in a high-risk industry he had ever seen".
Several possible explanations have been put forth to explain the failure to demonstrate a benefit: inadequate dosing, reduced drug delivery to tumour, lack of sustained potency and failure to select patients on the basis of having tumours in which EGFR presents a growth advantage (Dancey and Freidlin, 2003).
A lack of seipin causes failure to sustain the expression of key adipogenic factors, including peroxisome proliferator-activated receptor γ (PPARγ), which may explain the significantly reduced expression of adipogenic genes [ 12, 13].
This third phenotype includes errors in mitotic chromosome segregation, activation of, but failure to sustain, the spindle assembly checkpoint, diminished localisation of spindle checkpoint proteins at kinetochores, and a high rate of failure to complete cytokinesis.
This third phenotype includes errors in mitotic chromosome segregation, activation of, but failure to sustain, the spindle assembly checkpoint, decreased expression of Aurora B, and a high rate of failure to complete cytokinesis.
