Sentence examples for failure of segregation from inspiring English sources

Although we did not obtain these iPSCs in this experiment, this might be because the fibroblasts derived from the patient carried a ratio of m.3243A>G mtDNA mutation above the pathogenic threshold level, which limited the proliferative ability of the cells, resulting in the failure of segregation of the heteroplasmic mtDNA.

School Funding and Racial Segregation: A Tangled Web In a recent article marking the six decades since Brown, entitled "The Failure of Segregation," Jelani Cobb notes that the decision to attack segregation came about only after "the civil-rights establishment had fought a fierce and futile battle for the equal distribution of resources between black and white schools".

Stable microtubule-kinetochore attachment is critical for the correct chromosome segregation, so the failure of chromosome segregation in ERK3 deleted oocytes might be caused by the loss of protection of ERK3 for K-MT attachment.

Further, the forefathers and foremothers of white middle class women in America did not endure the Middle Passage, chattel slavery by predecessor governments to our current government, the failure of Reconstruction, segregation, and years of racial injustice in our country.

The γ-TuRC dissociates from centrosomes, the spindle fails to assemble resulting in failure of chromosome segregation.

Third, separase function appears to be critical for centriole separation only in the transition from the meiotic to mitotic cell cycle, while subsequent centrosome duplication cycles occurred normally, despite continued failure of chromosome segregation.

Depletion of haspin leads to a loss of cohesin association, premature chromatid separation and the failure of normal chromosome segregation [28 30].

In addition, ectopic co-expression of Rec8 and Sgo1 in mitotic Schizosaccharomyces pombe cells causes failure of sister chromatid segregation, presumably because of resistance of centromeric cohesin to separase-mediated cleavage [16].

This redistribution is consistent with studies in MDCK cysts that link the loss of PTEN activity with failure in segregation of PI 4,5 P2 from PI 3,4,5 P3, leading to their homogenous, rather than polarized, membrane distributions (Martin-Belmonte et al., 2007).

It is known that cells with FOXM1 depletion display mitotic spindle defects, centrosome amplification, chromosome mis-segregation, failure of cytokinesis, and mitotic catastrophe, which are essentially the same phenotypes displayed by neuroblastoma cells with MEIS2 depletion as described above.

Also, loss or gain of chromosomes can be consequence of segregation errors and cytokinesis failure leading to high chromosome instability.