Sentence examples for failure of receptor from inspiring English sources

In immature Cav1-deficient B cells, altered nanoscale organization of IgM-BCRs resulted in a failure of receptor editing and a skewed repertoire of B cells expressing immunoglobulin-μ heavy chains with hallmarks of poly- and auto-reactivity, which ultimately led to autoimmunity in mice.

There is evidence that MRAP may also play a role in ACTH binding and/or signalling, 31 and without MRAP, the MC2 receptor will not traffic efficiently to the cell surface leading to complete failure of receptor function.

Because we had found that failure of receptor editing of the Vk gene with autoreactive potential (A30-Vk2) is associated with the development of anti-DNA antibody in SLE, we next focused on anti-DNA autoantibody secreting B cells.

In some ju89 mutant animals the GFP-tagged receptor appeared diffused throughout the muscle tissue, consistent with the failure of the receptor to completely localize to synapses.

Failure of NMDA receptor hypofunction to induce a pathological reduction in PV-positive GABAergic cell markers.

Irrespective of the undisputable role of SP in rodent neurogenic plasma protein extravasation, the failure of NK1 receptor antagonists in the acute migraine attack convincingly discarded the hypothesis that meningeal plasma protein extravasation could be the underlying mechanism of migraine [26].

Disturbance of such mechanisms, e.g. failure of IP3 receptor function (reviewed in [23]) may lead to cell death.

Severe combined immunodeficiency A is characterised clinically by extreme radiosensitivity and by a complete absence of T and B cells due to a failure of the receptor recombination stage of V(D J recombination (Dvorak and Cowan, 2010).

Failure of post-receptor signaling has been noted as a fundamental mechanism of insulin resistance in uremic animals and in other disorders including injury, infection, aging and obesity and may reflect an important biological mechanisms in uremia [ 24].

Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) was originally described in a family of Irish and Scottish pedigree and initially thought to be a tumor necrosis factor (TNF) receptor-mediated disease, resulting from the failure of the TNF receptor to insert itself into cell membrane [ 28].

It has been reported that both GH and its receptor may translate to the nucleus and correlate with proliferative activity [ 13]; thus a failure of the hormone receptor complex to internalize could again prevent the biological activity of GH.